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Updated: Jan 26, 2026
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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Connexin37-Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II -Mediated Hypertension
Loïc Le Gal1, Maxime Pellegrin2, Tania Santoro1
11 Department of Medicine University of Lausanne Switzerland.
Journal of the American Heart Association
|April 5, 2019
Summary
Connexin37 (Cx37) deficiency lowers blood pressure in angiotensin II-dependent hypertension by altering signaling pathways. Loss of Cx37 impacts the angiotensin II type 2 receptor, suggesting a role in blood pressure regulation.
Area of Science:
- Cardiovascular Biology
- Renal Physiology
- Molecular Medicine
Background:
- Connexin37 (Cx37) is expressed in aortic and renal cells, implicated in hypertension.
- The role of Cx37 in regulating blood pressure, particularly in response to angiotensin II (Ang II), remains unclear.
Purpose of the Study:
- To investigate the role of Cx37 in angiotensin II-dependent hypertension.
- To determine if Cx37 deficiency alters the hypertensive response to Ang II.
Main Methods:
- Infusion of Ang II in wild-type and Cx37-deficient (Cx37-/-) mice.
- 2-kidney, 1-clip renal artery stenosis model (renin-dependent hypertension).
- N-nitro-l-arginine-methyl-ester treatment (renin-independent hypertension).
- Analysis of Ang II type 2 receptor (AT2R) expression and downstream signaling proteins.
Main Results:
- Cx37-/- mice exhibited a reduced increase in blood pressure during Ang II infusion and renal clipping.
- Loss of Cx37 selectively impaired the Ang II-dependent hypertensive response, but not renin-independent hypertension.
- Cx37 deficiency led to increased basal AT2R expression and altered signaling protein activation in aortas.
Conclusions:
- Cx37 plays a selective role in modulating Ang II signaling pathways.
- Cx37 influences hypertension primarily through the regulation of Ang II type 2 receptor expression.
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