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Updated: Jan 26, 2026

Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Towards a rational design of faecal transplant analogues
Olaf F A Larsen1, Anton H J Koning2, Peter J van der Spek2
1Vrije Universiteit Amsterdam, Athena Institute, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands. o.f.a.larsen@vu.nl.
Abstract:
Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5-6 species to maximize stability, efficiency, and minimize safety issues and production costs.
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