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Left atrial phasic function in hypertensive patients with significant aortic stenosis and preserved ejection fraction
Marijana Tadic1,2, Cesare Cuspidi3, Biljana Pencic4
1Department of Cardiology, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Heroja Milana Tepica 1, 11000, Belgrade, Serbia. marijana_tadic@hotmail.com.
Summary
Hypertension worsens left atrial (LA) function in patients with moderate to severe aortic stenosis (AS). Both blood pressure and AS severity independently impact LA function, highlighting the need for comprehensive assessment.
Area of Science:
- Cardiology
- Echocardiography
- Hypertension Research
Background:
- Aortic stenosis (AS) can affect cardiac function.
- The impact of hypertension on left atrial (LA) function in AS patients is not fully understood.
Purpose of the Study:
- To evaluate the influence of hypertension on left atrial (LA) function in patients with moderate and severe aortic stenosis (AS).
Main Methods:
- Cross-sectional study of 121 patients with moderate/severe AS and 79 controls.
- Comprehensive echocardiography to assess LA phasic function using volumetric and strain methods.
Main Results:
- Hypertension showed an additive negative impact on LA phasic function in AS patients.
- LA volume indexes increased, and emptying fractions decreased in AS patients compared to controls.
- Volumetric assessment revealed more prominent LA function differences than strain analysis.
Conclusions:
- Hypertension significantly impairs LA function in moderate to severe AS.
- Blood pressure and AS severity are independent predictors of LA phasic function.
- Volumetric LA function assessment remains crucial alongside strain analysis.
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