Related Experiment Video
Updated: Jan 26, 2026

Grade III Varicocele Surgical Treatment using Spermatic Vein-Superficial Abdominal Vein Shunt
Published on: August 23, 2024
Incidence of the MTHFR polymorphisms in patients with varicose veins
1Department of Emergency Aid and Disaster Management School of Health, Bozok University, Yozgat, Turkey.
Background:
Varicose vein disease is one of the most common inherited disorders worldwide that causes mental, cosmetic, medical, and socio-economic problems. Varicose vein formation is thought to be multifactorial and often develops through the interaction of environmental and genetic risk factors. Its incidence displays a trend parallel to the distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism worldwide. The objective of this study was to determine the incidence of MTHFR C677T and A1298C mutations in Turkish patients with varicose veins.
Material And Methods:
Our study included 98 patients with varicose veins; twenty-nine (29.6 %) males and 69 (70.4 %) females, with a mean age of 52.9 ± 14.7 (age range: 12-83) years. Polymorphisms were investigated by polymerase chain reaction (PCR) which is an enzymatic reaction of DNA amplification, and allele-specific hybridization.
Results:
The homozygous MTHFR C677T polymorphism was detected in 13 (13.3 %), and heterozygous MTHFR C677T polymorphism in 37 (37.7 %) patients. The homozygous and heterozygous MTHFR A1298C polymorphisms were found in nine (9.2 %), and 47 (47.9 %) patients, respectively. The combined double heterozygous genotype MTHFR C677T/MTHFR A1298C was identified in 19 (19.4 %) patients. The rates of factor V Leiden (FVL) and prothrombin gene (PT G20210A) polymorphisms were found as 11.2 %, and 4.1 %, respectively. Additionally, the majority of patients with thrombosed varicose veins were accompanied by FLV polymorphism.
Conclusion:
Our findings display that the rates of MTHFR C677T and A1298C genotypes are similar between patients with varicose veins and healthy subjects in Turkish society. However, should FLV or PG G20210A polymorphisms accompany these polymorphisms, then there might be a tendency to development of superficial venous thrombosis. Further studies are required to support these findings. HIPPOKRATIA 2017, 21(4): 175-179.
More Related Videos
09:58A Microbiomechanical System for Studying Varicosity Formation and Recovery in Central Neuron Axons
Published on: April 30, 2018
09:04Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
Related Concept Videos
Varicose Veins I: Introduction
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Single Nucleotide Polymorphisms-SNPs
Veins
Structure of Veins:
The structure of veins is specifically designed to assist in the low-pressure transportation of...