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Neonatal intestinal lactase activity.

L T Weaver, M F Laker, R Nelson

    Archives of Disease in Childhood
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Neonatal intestinal lactase activity increases rapidly after formula feeding, indicated by declining lactose excretion. Full-term infants show faster increases than preterm infants, reaching over 98% efficiency within five days.

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    Area of Science:

    • Neonatal physiology
    • Gastrointestinal development
    • Nutritional science

    Background:

    • Intestinal lactase is crucial for lactose digestion in neonates.
    • Premature infants may have delayed development of digestive enzymes.
    • Assessing lactase activity is important for optimizing infant nutrition.

    Purpose of the Study:

    • To measure sequential changes in intestinal lactase activity in neonates.
    • To correlate lactase activity development with gestational age.
    • To determine the efficiency of lactose digestion in early infancy.

    Main Methods:

    • Indirect measurement of lactase activity using differential excretion of lactose and lactulose.
    • Analysis of urinary lactose:lactulose excretion ratios in formula-fed neonates.

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  • Comparison of lactase activity development based on gestational age.

    • Main Results:

    • A daily decline in urinary lactose:lactulose ratios indicated increasing intestinal lactase activity post-feeding.
    • Full-term infants showed a fivefold greater decline in lactosuria than infants born at 28 weeks gestation.
    • Lactose hydrolysis efficiency exceeded 98% within five days of feeding, even in very preterm infants.

    Conclusions:

    • Intestinal lactase activity matures rapidly in neonates following formula initiation.
    • Gestational age significantly influences the rate of lactase enzyme development.
    • Early and efficient lactose digestion is achievable even in very preterm neonates.