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Published on: April 1, 2019
Vitamin D receptor polymorphisms and melanoma
Alina F Vasilovici1, Lavinia Elena Grigore1,2, Loredana Ungureanu1
1Department of Dermatology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Vitamin D receptor (VDR) gene variations influence melanoma risk and progression. This systematic review highlights the vitamin D pathway
Area of Science:
- Dermatology
- Genetics
- Endocrinology
Background:
- Melanoma is an aggressive skin cancer with complex etiology.
- Vitamin D plays a role in melanoma development and progression.
- The vitamin D receptor (VDR) mediates vitamin D's biological actions.
Purpose of the Study:
- To systematically review the association between VDR gene polymorphisms and melanoma risk.
- To analyze VDR gene variants' impact on melanoma progression.
Main Methods:
- Systematic literature review.
- Analysis of studies examining VDR gene polymorphisms (FokI, TaqI, BsmI, ApaI, Cdx2, EcoRV, BglI) and melanoma.
Main Results:
- Individual studies on VDR gene polymorphisms and melanoma risk yielded controversial results.
- The vitamin D pathway is implicated in cutaneous melanoma pathogenesis and progression.
Conclusions:
- VDR gene polymorphisms may influence melanoma risk and progression.
- Gene-environment interactions are crucial in melanoma.
- Further prospective studies with genotype and phenotype data are needed to elucidate the vitamin D-melanoma association.
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