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Process utilities for topical treatment in atopic dermatitis
Jenny Retzler1,2, Adam Smith3, Matthew Reaney4
1York Health Economics Consortium, University of York, York, UK. j.retzler@hud.ac.uk.
Summary
Topical treatments for atopic dermatitis (AD) negatively impact quality of life (QoL). More intensive skincare regimens, especially those involving topical corticosteroids, lead to greater disutility for patients with AD.
Area of Science:
- Dermatology
- Health Economics
- Quality of Life Research
Background:
- Atopic dermatitis (AD) management often involves frequent topical treatments.
- The application burden and cosmetic properties of topical AD treatments can diminish patient quality of life (QoL).
- Systemic therapies may allow for reduced topical application, potentially improving QoL.
Purpose of the Study:
- To quantify the utility and disutility associated with topical treatment processes for atopic dermatitis.
- To assess the impact of different skincare regimens on patient quality of life.
Main Methods:
- Development of seven vignettes depicting various skincare regimens for moderate-to-severe AD, informed by healthcare professionals.
- Administration of time trade-off exercises to 484 general population respondents for each vignette.
- Calculation of utility values and disutilities, with analysis of variance (ANOVA) used to compare skincare regimens.
Main Results:
- Utility values decreased as skincare regimen intensity increased.
- Skincare regimens with topical corticosteroids and emollients showed significantly lower utility values compared to regimens for patients with good disease control (p < 0.001).
- The greatest disutilities were observed between regimens involving topical corticosteroids/emollients and those for patients with well-controlled disease.
Conclusions:
- Topical AD treatments negatively affect QoL, with effects escalating with application frequency and duration.
- Further research is required to understand the interplay of health and process utilities in medical decision-making for AD management.
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