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Programmed death-1 inhibitor for occupational intrahepatic cholangiocarcinoma caused by chlorinated organic solvents

Shogo Tanaka1, Shoji Kubo1

  • 1Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Journal of Hepato-Biliary-Pancreatic Sciences
|April 5, 2019
PubMed

Insights

The first case of recurrent occupational cholangiocarcinoma was treated with a programmed death-1 inhibitor. This immunotherapy showed positive results in reducing lymph node metastasis after surgery.

Area of Science:

  • Hepatobiliary Surgery
  • Medical Oncology
  • Immunotherapy

Background:

  • Cholangiocarcinoma is a rare cancer of the bile ducts.
  • Recurrent disease presents a significant treatment challenge.
  • Occupational exposure is a potential risk factor.

Observation:

  • A patient with recurrent occupational cholangiocarcinoma underwent curative hepatectomy.
  • Metastasis was observed in para-aortic lymph nodes.
  • Treatment with a programmed death-1 inhibitor was initiated.

Findings:

  • The programmed death-1 inhibitor was administered every two weeks.
  • After seven cycles, imaging revealed diminished lymph node size.
  • Positron emission tomography showed reduced metabolic activity (18F-fluorodeoxyglucose uptake) in the lymph nodes.

Implications:

  • Programmed death-1 inhibitors show promise in treating recurrent cholangiocarcinoma.
  • Immunotherapy may be a viable option for advanced biliary tract cancers.
  • Further research is warranted to explore this treatment modality.
Keywords:
CA19-9NivolumabOccupational cholangiocarcinomaPD-1 inhibitorProgrammed death-ligand 1

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