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Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
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Cell Adhesion in Plants01:14

Cell Adhesion in Plants

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Laminins are the Adhesive Proteins of Basal Lamina00:55

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
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Multifunctional Biomedical Adhesives.

Rattapol Pinnaratip1, Mohammad Saleh Akram Bhuiyan1, Kaylee Meyers1

  • 1Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.

Advanced Healthcare Materials
|April 5, 2019
PubMed
Summary
This summary is machine-generated.

This review explores advanced multifunctional biomedical adhesives, moving beyond single-function designs. These innovative bioadhesives offer enhanced properties like antimicrobial activity and drug delivery for improved medical applications.

Keywords:
biomedical adhesivesmultifunctionalitypassive and active designstimuli-responsiveness

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Adhesive Technology

Background:

  • Current biomedical adhesives primarily offer mechanical support.
  • There is a growing need for advanced bioadhesives with multiple functionalities.
  • Existing single-function adhesives limit their therapeutic potential.

Purpose of the Study:

  • To review recent advancements in multifunctional bioadhesives.
  • To categorize bioadhesives based on their design (passive vs. active).
  • To highlight novel functionalities and applications of these advanced materials.

Main Methods:

  • Literature review of recent scientific publications on bioadhesives.
  • Categorization of multifunctional bioadhesives into passive and active types.
  • Analysis of inherent properties and external stimuli-responsive mechanisms.

Main Results:

  • Passive multifunctional bioadhesives possess inherent properties like antimicrobial effects, self-healing, and enhanced cell integration.
  • Active multifunctional bioadhesives respond to external triggers (pH, light, temperature) for controlled drug release or binding modulation.
  • A wide range of novel functionalities are being developed for improved biomedical applications.

Conclusions:

  • Multifunctional bioadhesives represent a significant leap beyond traditional single-function materials.
  • Both passive and active design strategies offer diverse and valuable functionalities for medical use.
  • Continued research in this area promises to revolutionize tissue repair and drug delivery systems.