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Magnesium alginate in children with uncontrolled asthma

M Miraglia Del Giudice1, C Indolfi1, G Ciprandi2

  • 1Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples, Italy.

Journal of Biological Regulators and Homeostatic Agents
|April 5, 2019
PubMed

Insights

Gastroesophageal reflux disease (GERD) is common in children with asthma and may worsen their condition. Proton pump inhibitors (PPIs) are often used, but their effectiveness for respiratory symptoms and potential side effects are not well-established.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology

Background:

  • Gastroesophageal reflux disease (GERD) frequently co-occurs with pediatric asthma.
  • GERD may negatively impact asthma control and management in children.

Discussion:

  • Proton pump inhibitors (PPIs) are commonly prescribed for asthmatic children with suspected GERD.
  • The efficacy of PPIs in improving respiratory symptoms and asthma control in this population remains uncertain.
  • Potential adverse effects associated with long-term PPI use warrant consideration.

Key Insights:

  • A significant association exists between GERD and childhood asthma.
  • The therapeutic benefit of PPIs for respiratory symptoms in asthmatic children is not well-established.
  • Risk-benefit assessment is crucial when considering PPIs for pediatric GERD and asthma.

Outlook:

  • Further research is needed to clarify the role of GERD in pediatric asthma.
  • Investigating alternative or targeted therapies for GERD in asthmatic children is warranted.
  • Clinical guidelines should reflect the current evidence regarding PPI use in this demographic.

Keywords:
asthmaasthma controlchildrengastroesophageal reflux diseasemagnesium alginateproton pump inhibitor

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