Serum oxidative stress, inflammatory response and platelet activation in patients with vascular vertigo

Area of Science:

• Biomedical Science
• Clinical Medicine
• Pathophysiology

Background:

• Vascular vertigo (VV) is a common condition with complex underlying mechanisms.
• Oxidative stress and inflammatory responses are implicated in various vascular and neurological disorders.

Purpose of the Study:

• To investigate the correlation and clinical significance of oxidative stress and inflammatory markers in vascular vertigo.
• To compare these markers between patients with vascular vertigo, non-vascular vertigo, and healthy controls.

Main Methods:

• Serum levels of interleukin-6 (IL-6), superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), and P-Selectin (CD62P) were measured.
• Subjects were categorized into vascular vertigo, non-vascular vertigo, and control groups.
• Statistical analyses were performed to compare marker levels and assess correlations.

Main Results:

• Patients with vascular vertigo exhibited significantly higher levels of IL-6, TNF-α, MDA, and CD62P compared to non-vascular vertigo and control groups (P < 0.05).
• Vascular vertigo patients showed significantly lower SOD levels (P < 0.05).
• No significant differences in markers were observed between non-vascular vertigo and control groups (P > 0.05).
• A weak linear correlation was found between TNF-α and low-density lipoprotein in vascular vertigo patients (P = 0.025).

Conclusions:

• Elevated oxidative stress and inflammatory responses are associated with vascular vertigo.
• These conditions may contribute to abnormal lipid metabolism and promote VV development.
• Platelet activation appears to play a role in the pathophysiology of vascular vertigo.