Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Towards 'the best DOAC'?]

Sander van Doorn1, Frans H Rutten1, G J Geersing1,2

  • 1UMC Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde.

Nederlands Tijdschrift Voor Geneeskunde
|April 5, 2019
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excess cardiovascular risk associated with community-acquired lower respiratory tract infections: a population-based nested self-controlled case-series.

BMC medicine·2026
Same author

Comparison of local large language models for extraction of signs and symptoms data from electronic health records.

PloS one·2026
Same author

Out-of-hours primary care management for patients with heart failure.

ESC heart failure·2026
Same author

Defining delayed and missed diagnosis of acute and chronic coronary syndromes: a modified Delphi consensus method.

Open heart·2026
Same author

Voice recognition as an innovative method to identify and monitor heart failure - a review.

Heart failure reviews·2026
Same author

Wrist-type home blood pressure monitoring device improves usability and preserves sleep quality compared with conventional ambulatory monitoring.

Journal of hypertension·2026
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Direct oral anticoagulants (DOACs) offer alternatives for stroke prevention in atrial fibrillation and venous thromboembolism treatment. This expert consensus compares DOACs and vitamin K antagonists, based on indirect evidence due to limited head-to-head trials.

Area of Science:

  • Pharmacology and Therapeutics
  • Cardiovascular Medicine
  • Hematology

Background:

  • Direct oral anticoagulants (DOACs) are gaining prominence for stroke prevention in atrial fibrillation (AF) and venous thromboembolism (VTE) treatment.
  • Traditional anticoagulation therapy involves vitamin K antagonists (VKAs), which have established protocols but require frequent monitoring.

Purpose of the Study:

  • To provide guidance on the differences between various available DOACs.
  • To compare DOACs with traditional vitamin K antagonist treatments.
  • To offer an expert consensus on DOAC selection and use in clinical practice.

Main Methods:

  • The study is a short overview and expert consensus.
  • Comparisons are predominantly based on indirect meta-analyses.

Related Experiment Videos

  • Observational evidence is utilized to infer differences and efficacy.

    • Main Results:

    • The overview highlights potential differences among DOACs, although direct comparative trials are lacking.
    • Indirect evidence suggests varying profiles for different DOACs and comparisons to VKAs.
    • The findings emphasize the need for cautious interpretation due to the reliance on indirect data.

    Conclusions:

    • Expert consensus suggests DOACs are valuable therapeutic options, but careful consideration of individual patient factors is necessary.
    • The current evidence base, primarily from indirect comparisons, necessitates a nuanced approach to DOAC selection.
    • Further head-to-head trials are needed to definitively establish the comparative efficacy and safety of different DOACs.