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Updated: Jan 26, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
[Loss is gain? Discarding TNF-α inhibitors]
Matthijs M Versteegh1,2, Arthur E Attema3, Carin A Uyl-de Groot1
1Erasmus Universiteit, Institute for Medical Technology Assessment, Rotterdam.
Abstract:
According to a recent study, stopping the prescription of TNF inhibitors is a cost-effective decision at various willingness-to-accept thresholds. Discontinuing the prescription of the drug may lead to a minor loss in health - expressed in quality adjusted life years - but results in significant societal savings. In our commentary, we stress that willingness-to-pay thresholds should not be completely replaced by the willingness-to-accept threshold, also when it concerns health losses. Loss aversion can be viewed as either a relevant societal phenomenon or an irrationality that should not guide decision making.
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