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The Relationship Between Hypoadiponectinemia and Cardiovascular Events in Liver Transplant Recipients

Mohammad Bilal Siddiqui1, Samarth Patel1, Tamoore Arshad2

  • 1Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, VA.

Transplantation
|April 5, 2019
PubMed

Insights

Low adiponectin (hypoadiponectinemia) significantly predicts cardiovascular disease (CVD) events after liver transplantation (LT). This finding is independent of other risk factors, aiding future CVD risk assessment in LT recipients.

Area of Science:

  • Cardiology
  • Hepatology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) is a major cause of death post-liver transplantation (LT).
  • Serum adiponectin levels are linked to CVD outcomes, but its role in hypoadiponectinemia after LT is unclear.

Purpose of the Study:

  • To prospectively investigate the association between low serum adiponectin levels and the risk of CVD events in liver transplant recipients (LTR).

Main Methods:

  • 130 liver transplant recipients were enrolled and followed for CVD events.
  • Hypoadiponectinemia was defined as serum adiponectin <10 µg/mL.
  • A composite CVD outcome included myocardial infarction, angina, revascularization, stroke, or cardiac death.

Main Results:

  • A total of 20 CVD events occurred during a median follow-up of 45 months.
  • Hypoadiponectinemia was significantly associated with an increased risk of CVD events (HR, 3.519; P=0.024).
  • This association remained significant and independent of traditional CVD risk factors and immunosuppression.

Conclusions:

  • Low serum adiponectin is a strong, independent predictor of future cardiovascular events in liver transplant recipients.
  • Incorporating adiponectin levels into clinical practice can improve CVD risk assessment post-LT.
Abstract

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