Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function defects in chronic alcoholism.

D P Mikhailidis, W J Jenkins, M A Barradas

    British Medical Journal (Clinical Research Ed.)
    |September 20, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess.

    Current vascular pharmacology·2023
    Same author

    Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency.

    Current vascular pharmacology·2023
    Same author

    Nonalcoholic Fatty Pancreas Disease: Role in Metabolic Syndrome, "Prediabetes," Diabetes and Atherosclerosis.

    Digestive diseases and sciences·2021
    Same author

    Multifocal arterial disease: clinical implications and management.

    Current opinion in cardiology·2020
    Same author

    Preface.

    Current vascular pharmacology·2018
    Same author

    Daylight saving time and myocardial infarction: should we be worried? A review of the evidence.

    European review for medical and pharmacological sciences·2018
    Same journal

    Early retirement for consultants.

    British medical journal (Clinical research ed.)·2010
    Same journal

    From COMAR: Essential troika of teaching, research, and clinical care.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Parliament's two way pull on the NHS.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Conference Report: After the summit.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Council election: South Western regional vacancy 1988-90.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Health managers support taxation based service.

    British medical journal (Clinical research ed.)·2010
    See all related articles

    Alcohol significantly impairs platelet function and reduces platelet counts, increasing bleeding risk. Abstinence for 2-3 weeks restores normal platelet function and counts in alcoholic patients.

    Area of Science:

    • Hematology
    • Toxicology
    • Internal Medicine

    Background:

    • Chronic heavy alcohol consumption is linked to bleeding disorders.
    • Alcohol's impact on platelet function and count is not fully understood.

    Purpose of the Study:

    • To assess platelet function and count in alcoholic patients upon admission and during abstinence.
    • To determine the reversibility of alcohol-induced platelet dysfunction.

    Main Methods:

    • Assessed platelet responsiveness to aggregating agents (adrenaline, ADP, collagen).
    • Measured platelet counts and Simplate II bleeding times.
    • Monitored changes during 2-3 weeks of hospital abstinence.

    Main Results:

    • On admission, alcoholic patients showed reduced platelet aggregation and thromboxane A2 release, with lower platelet counts and prolonged bleeding times.

    Related Experiment Videos

  • Platelet function and counts normalized or became hyper-responsive during abstinence.
  • Bleeding times correlated with improved platelet aggregation, thromboxane A2 release, platelet count, and reduced prior ethanol consumption.

    • Conclusions:

    • Chronic alcohol ingestion inhibits platelet function reversibly upon abstinence.
    • Impaired platelet function and reduced counts may contribute to bleeding diathesis in alcoholism.
    • This dysfunction may increase the risk of gastrointestinal hemorrhage in heavy drinkers.