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Effect of irradiation with intravascular laser on the hemodynamic variables of hypertensive patients: Study protocol
Adriana Paula Jordão Isabella1, Jéssica Tayane Costa Silva2, Tamiris da Silva3
1PhD student of Post Graduate Program in Biophotonics.
Insights
This study investigates low-level laser therapy (LLLT) for high blood pressure (HBP). The noninvasive intravascular laser irradiation of blood (ILIB) technique aims to improve hemodynamic parameters and treatment adherence in hypertensive patients.
Area of Science:
- Cardiovascular research
- Biomedical engineering
- Photomedicine
Background:
- High blood pressure (HBP) presents significant morbidity and mortality risks, with suboptimal control rates.
- Effective non-pharmacological interventions are needed to improve quality of life for hypertensive patients.
- Low-level laser therapy (LLLT) demonstrates potential for photobiological responses impacting vascular function and systemic effects, as seen in intravascular laser irradiation of blood (ILIB).
Purpose of the Study:
- To evaluate the effect of photobiomodulation via ILIB on hemodynamic parameters in hypertensive and normotensive individuals.
- To explore LLLT as a non-pharmacological adjunct therapy for hypertension management.
- To assess the potential of ILIB to enhance patient adherence to treatment regimens.
Main Methods:
- A protocol involving noninvasive ILIB using a transcutaneous laser applied over the radial artery.
- Forty-four participants will be divided into four groups for protocol sessions.
- Blood samples will be analyzed for C-reactive protein, interleukin 6, and nitric oxide levels pre-procedure, post-therapy, and one month after completion.
Main Results:
- Statistical analysis will employ descriptive and inferential methods using SPSS version 24.0.
- Results will be presented in tables and graphs to illustrate findings.
- A significance level of α = 0.05 will be adopted for all statistical tests.
Conclusions:
- Hypertension management requires both pharmacological and non-pharmacological approaches.
- While animal studies suggest photobiomodulation has hypotensive effects, human data is limited.
- This research seeks to validate non-pharmacological photobiomodulation therapy for hypertensive patients, aiming to improve adherence and reduce hypertension-related morbidity and mortality.
Background:
High blood pressure (HBP) is a multifactorial clinical condition, with a high morbidity and mortality rate and low rates of control. Due to its high prevalence, it is necessary to search for methods which aim to improve the quality of life of hypertensive patients. Studies have shown that low level laser therapy (LLLT) is capable of inducing a photobiological response within the cells which modifies the micro and macrovascular response; this accompanies evidence showing the systemic effects of intravascular laser irradiation of blood (ILIB). In the hypothesis that the use of LLLT can influence blood pressure levels, and perhaps facilitate adherence to treatment, this study aims to present a clinical research protocol with the goal of determining the effect of photobiomodulation in relation to changes in the hemodynamic parameters of hypertensive and normotensive patients.
Method:
Forty-four participants, frequent attendees of an ambulatory university clinic, will be subdivided into 4 groups, and then submitted to protocol sessions of ILIB. The technique is noninvasive and consists of a laser which is attached to a bracelet which has been specifically developed for the light beam to be transcutaneously carried over the radial artery. Before the procedure, at the end of the photobiomodulation cycles, and 1 month after the end of therapy, blood samples will be collected for the evaluation of C-reactive protein, interleukin 6, and nitric oxide, to be analyzed by immunoturbidimetric, ELISA, and Griess reactions, respectively.
Analysis Of Results:
Results will be analyzed using descriptive and inferential statistics and will be compiled into tables and/or graphs, with the help of SPSS version 24.0 with the adopted significance level for all tests being α = 0.05.
Discussion:
The treatment of HBP involves both pharmacological and nonpharmacological therapy. Animal studies with photobiomodulation have previously shown hypotensive effects. Gaps in the literature exist regarding the applicability of this nonpharmacological therapy in humans. This study aims to consider the possibility of offering nonpharmacological therapy to hypertensive patients with the goal of increasing adherence to the treatment as well as minimizing morbidity and mortality caused by hypertension.
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