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Follicular cholecystitis: clinicopathologic associations
Behzad Salari1, Neda Rezaee1, Angus Toland1
1Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA 63110.
Human Pathology
|April 5, 2019
Summary
Follicular cholecystitis (FC) is often linked to distal biliary obstruction. This gallbladder condition frequently co-occurs with chronic cholecystitis or lymphocytic cholecystitis.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Pathology
Background:
- Follicular cholecystitis (FC) is an uncommon gallbladder condition.
- Its precise causes and associations remain incompletely understood.
Purpose of the Study:
- To investigate the clinicopathologic associations of follicular cholecystitis.
- To better define and characterize this gallbladder pathology.
Main Methods:
- Retrospective review of hematoxylin and eosin slides from cholecystectomy cases diagnosed with FC.
- Analysis of clinical data from 1991 to 2017.
- Documentation of concurrent chronic cholecystitis (CC) and lymphocytic cholecystitis (LC).
Main Results:
- Forty-three cases of FC were identified.
- 88.4% of FC cases showed co-existing LC, CC, or both.
- Distal biliary obstruction was present in 76.7% of patients, regardless of other histologic findings.
- FC associated with CC was more common in females and linked to cholelithiasis.
- FC without CC predominantly occurred in males and was associated with LC.
Conclusions:
- Follicular cholecystitis is strongly associated with distal extrahepatic biliary obstruction.
- FC identified during cholecystectomy may necessitate further investigation for biliary tract obstruction.
- FC frequently presents with other gallbladder histologic abnormalities like CC and/or LC.
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