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Accelerated drug discovery by rapid candidate drug identification
Fredrik Bergström1, Bo Lindmark1
1Drug Metabolism and Pharmacokinetics, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Drug Discovery Today
|April 5, 2019
Summary
A clear candidate drug target profile (CDTP) is essential for efficient drug discovery. This profile guides compound optimization and enables rapid identification of promising drug candidates early in development.
Area of Science:
- Drug discovery and development
- Medicinal chemistry
- Preclinical research
Background:
- Candidate drugs (CDs) are often synthesized early but nominated late in drug discovery.
- A well-defined candidate drug target profile (CDTP) is crucial for timely nomination.
- Preclinical teams need a clear understanding of the ultimate goal for effective compound optimization.
Purpose of the Study:
- To emphasize the importance of a robust candidate drug target profile (CDTP) at the outset of lead generation (LG).
- To highlight the necessity of a structured screening cascade with clear progression criteria.
- To facilitate the rapid identification and selection of potential candidate drugs.
Main Methods:
- Defining a comprehensive CDTP aligned with the disease target product profile (TPP).
- Implementing a screening cascade with balanced progression criteria based on the CDTP.
- Integrating CDTP criteria into compound property optimization and project team understanding.
Main Results:
- Early establishment of a CDTP accelerates the identification of potential candidate drugs.
- A well-designed screening cascade effectively filters compounds and progresses viable candidates.
- Clear criteria ensure alignment between compound optimization and ultimate drug selection goals.
Conclusions:
- A proactive approach using a detailed CDTP is vital for efficient candidate drug selection.
- Structured screening cascades are essential for navigating the drug discovery pipeline.
- Optimizing the early stages of drug discovery leads to faster identification of viable drug candidates.
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