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A unified (but in fact not fully testable) model of preeclampsia triggering

Gerard Chaouat1

  • 1U976 INSERM Hopital Saint Louis Pavillon Bazin, 75010 Paris France.

Journal of Reproductive Immunology
|April 5, 2019
PubMed

In this summary of my presentation in the last Reunion workshop I discuss a few assertions on preeclampsia, then turn on a (not fully testable) model where an embryonic defect in expression of embryo/ placental regulatory proteins results in complement activation, itself responsible for a down regulation of the T regs activity, resulting in a very early lack of complete down regulation of the preimplantation decidual inflammation, causing in the post implantation stage a low grade but chronic inflammatory state.

Keywords:
Pre-Eclampsia embryo complement Treg inflammation

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