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A current overview of corticosteroid use in active ulcerative colitis
Marco Salice1, Fernando Rizzello1, Carlo Calabrese1
1a Department of Internal Medicine and Gastroenterology , University of Bologna , Bologna , Italy.
Corticosteroids are essential for managing active ulcerative colitis (UC) flares, especially severe cases, and offer alternatives for mild to moderate cases. However, they are not suitable for long-term maintenance therapy due to adverse effects.
Area of Science:
- Gastroenterology
- Internal Medicine
- Pharmacology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease causing colon inflammation.
- While new biologics exist, corticosteroids remain vital for active UC management.
- This review focuses on the role of corticosteroids in UC treatment.
Purpose of the Study:
- To review the current literature on the importance of corticosteroid use in ulcerative colitis treatment.
- To summarize expert opinions and current practice guidelines regarding corticosteroid therapy for UC.
Main Methods:
- Literature review of scientific publications.
- Inclusion of expert opinion statements.
- Consideration of current practice guidelines for ulcerative colitis management.
Main Results:
- Corticosteroids are the primary treatment for severe UC.
- They effectively induce remission in mild to moderate flares unresponsive to mesalazine.
- Poorly absorbed steroids (Budesonide MMX, Beclomethasone dipropionate) and topical corticosteroids are alternatives for specific UC cases.
Conclusions:
- Corticosteroids are crucial for inducing remission in active ulcerative colitis.
- Topical and poorly absorbed formulations offer targeted treatment options.
- Corticosteroids are not recommended for maintenance therapy due to adverse effects.
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