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Expression and Significance of Th17 Cells and Related Factors in Patients with Autoimmune Hepatitis

Jihong An1

  • 1Department of Infectious Diseases, Inner Mongolia People's Hospital, Inner Mongolia 010017, China.

Combinatorial Chemistry & High Throughput Screening
|April 6, 2019
PubMed

Insights

Increased Th17 cells and related factors like IL-17 and TNF-α are linked to liver damage in Autoimmune Hepatitis (AIH) patients. These markers may help monitor disease severity.

Area of Science:

  • Immunology
  • Hepatology
  • Autoimmune Diseases

Background:

  • Autoimmune Hepatitis (AIH) is a chronic liver disease characterized by immune system attack on liver cells.
  • T helper 17 (Th17) cells and regulatory T (Treg) cells play crucial roles in immune regulation and are implicated in autoimmune conditions.

Purpose of the Study:

  • To investigate the expression of Th17 cells and associated cytokines in the peripheral blood of AIH patients.
  • To determine the clinical significance of Th17 cells and related factors in monitoring AIH disease activity and liver damage.

Main Methods:

  • A retrospective study included 100 AIH patients and 100 healthy controls.
  • Enzyme-linked immunosorbent assay (ELISA) measured serum levels of IL-17, IL-6, IL-21, and TNF-α.
  • Flow cytometry assessed the frequency of Th17 and Treg cells in peripheral blood.

Main Results:

  • AIH patients exhibited significantly higher serum levels of liver enzymes (ALT, AST) and inflammatory cytokines (IL-17, IL-6, IL-21, TNF-α) compared to controls.
  • A higher frequency of Th17 cells and a lower frequency of Treg cells were observed in AIH patients.
  • Serum IL-17, TNF-α levels, and Th17 cell frequency positively correlated with liver damage markers (ALT, AST), while Treg cell frequency showed a negative correlation.

Conclusions:

  • Th17 cell frequency and associated factors (IL-17, TNF-α) are significantly elevated in AIH patients.
  • These findings suggest that Th17 cell-related pathways are involved in the pathogenesis of liver damage in AIH.
  • Th17 cell frequency and related cytokines may serve as potential biomarkers for monitoring AIH disease severity.
Abstract

Keywords:
Asia-pacific regionIL-17TNF-αTh17 cellsautoimmune hepatitisliver damage.

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