Potentiometric sensor based on novel flowered-like Mg-Al layered double hydroxides/multiwalled carbon nanotubes...

Nowadays, development of highly efficient potentiometric sensors attracts the attention of many researchers over the world; due to the great expansion of portable analytical devices. This study aims to apply a current development to the construction and sense of carbon paste sensors based on flowered-like Mg-Al layered double hydroxides/multiwalled carbon nanotubes (FLLDH/MWCNTs) (sensor І), FLLDH/titanate nanotubes (TNTs) (sensor ІІ) and MWCNTs/TNTs (sensor ІІІ) nanocomposites for bambuterol hydrochloride analysis; to enhance the potentiometric response towards determination of the drug. The sensors exhibited excellent Nernstian slopes 58.8 ± 0.5, 58.5 ± 0.8 and 57.4 ± 0.7 mV/decade with linear working ranges of 1.0 × 10^-7-1.0 × 10^-2, 1.0 × 10^-6-1.0 × 10^-2 and 1.0 × 10^-7-1.0 × 10^-2 mol L^-1, detection limits 2.3 × 10^-8, 2.5 × 10^-7and 7.5 × 10^-8 mol L^-1 and quantification limits of 7.6 × 10^-8, 8.3 × 10^-7and 2.5 × 10^-7 mol L^-1 for sensor І, ІІ and ІІІ, respectively. The selectivity behaviour of the investigated sensors was tested against biologically important blood electrolytes (Na⁺, K⁺, Mg²⁺, Ca²⁺). The proposed analytical method was successfully applied for BAM determination in pure drug, pharmaceutical products, surface water, human plasma and urine samples with excellent recovery data (99.62, 99.10 and 98.95%) for the three sensors, respectively.