Characterizations and interfacial reinforcement mechanisms of multicomponent biopolymer based scaffold

It is difficult for a single component biopolymer to meet the requirements of scaffold at present. The development of multicomponent biopolymer based scaffold provides an effective method to solve the issue based on the advantages of each kind of the biomaterials. However, the compatibility between different components might be very poor due to the difficulties in forming strong interfacial bonding, and thereby significantly degrading the integrated mechanical properties of the scaffold. In recent years, interface phase introduction, surface modification and in situ growth have been the major strategies for enhancing interfacial bonding. This article presents a comprehensive overview on the research in the area of constructing multicomponent biopolymer based scaffold and reinforcing their interfacial properties, and more importantly, the interfacial bonding mechanisms are systematically summarized. Detailly, interface phase introduction can build a bridge between biopolymer and other components to form strong interface bonding with the two phases under the action of interface phase. Surface modification can graft organic molecules or polymers containing functional groups onto other components to crosslink with biopolymer. In situ growth can directly in situ synthesize other components with the action of nucleating agent serving as an adherent platform for the nucleation and growth of other components to biopolymer surface by chemical bonding. In addition, the mechanical properties (including strength and modulus) and biological properties (including bioactivity, cytocompatibility and biosensing in vitro, and tissue compatibility, bone regeneration capacity in vivo) of multicomponent biopolymer based scaffold after interfacial reinforcing are also reviewed and discussed. Finally, suggestions for further research are given with highlighting the need for specific investigations to assess the interface formation, structure, properties, and more in vivo studies of scaffold before applications.