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Human bocaviruses and paediatric infections

Andreas Christensen1, Olli Kesti2, Varpu Elenius2

  • 1Department of Medical Microbiology, St Olavs Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

The Lancet. Child & Adolescent Health
|April 6, 2019
PubMed

Insights

Human bocavirus 1 (HBoV1) causes various childhood respiratory illnesses. Diagnosis requires advanced methods like quantitative PCR and serology due to persistent viral DNA.

Area of Science:

  • Virology
  • Pediatric Infectious Diseases

Background:

  • Human bocavirus 1 (HBoV1) identified in 2005, a member of the Parvoviridae family.
  • HBoV1 is linked to a range of respiratory conditions in children.
  • Other bocaviruses (HBoV2-4) found in fecal samples have uncertain disease roles.

Purpose of the Study:

  • To review current knowledge on human bocaviruses.
  • To emphasize the clinical significance and diagnosis of HBoV1.

Main Methods:

  • Literature review of studies on human bocaviruses.
  • Analysis of diagnostic approaches for HBoV1 infection.

Main Results:

  • HBoV1 is associated with common cold, otitis media, pneumonia, bronchiolitis, and asthma exacerbations in children.
  • HBoV1 DNA persistence in secretions complicates standard PCR diagnosis.
  • Quantitative PCR, serology, mRNA, and antigen detection show diagnostic promise.

Conclusions:

  • HBoV1 is a significant pathogen in pediatric respiratory infections.
  • Advanced diagnostic techniques are crucial for accurate HBoV1 detection.
  • Further research into HBoV1 pathogenesis and diagnostics is warranted.

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