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Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
Published on: October 31, 2019
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Human bocaviruses and paediatric infections.
Andreas Christensen1, Olli Kesti2, Varpu Elenius2
1Department of Medical Microbiology, St Olavs Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
The Lancet. Child & Adolescent Health
|April 6, 2019
Summary
Human bocavirus 1 (HBoV1) causes various childhood respiratory illnesses. Diagnosis requires advanced methods like quantitative PCR and serology due to persistent viral DNA.
Area of Science:
- Virology
- Pediatric Infectious Diseases
Background:
- Human bocavirus 1 (HBoV1) identified in 2005, a member of the Parvoviridae family.
- HBoV1 is linked to a range of respiratory conditions in children.
- Other bocaviruses (HBoV2-4) found in fecal samples have uncertain disease roles.
Purpose of the Study:
- To review current knowledge on human bocaviruses.
- To emphasize the clinical significance and diagnosis of HBoV1.
Main Methods:
- Literature review of studies on human bocaviruses.
- Analysis of diagnostic approaches for HBoV1 infection.
Main Results:
- HBoV1 is associated with common cold, otitis media, pneumonia, bronchiolitis, and asthma exacerbations in children.
- HBoV1 DNA persistence in secretions complicates standard PCR diagnosis.
- Quantitative PCR, serology, mRNA, and antigen detection show diagnostic promise.
Conclusions:
- HBoV1 is a significant pathogen in pediatric respiratory infections.
- Advanced diagnostic techniques are crucial for accurate HBoV1 detection.
- Further research into HBoV1 pathogenesis and diagnostics is warranted.
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