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Dronabinol use in France between 2004 and 2017
S Lejczak1, H Rousselot2, P Di Patrizio3
1Department of neurology, hôpital Central, Nancy university hospital, CHRU, 29, avenue du Maréchal-de-Lattre-de-Tassigny CO n(o)34, 54035 Nancy cedex, France; Service interdiciplinaire de soins de support aux patients en oncologie (SISSPO), institute of oncology of Lorraine « Alexis Vautrin », 6, avenue de Bourgogne, 54519 Vandœuvre-les-Nancy cedex, France.
Dronabinol, a delta-9-tetrahydrocannabinol extract, is prescribed for chronic pain in France. This study found it reduced pain by 30-50% in 59% of patients, primarily those with multiple sclerosis.
Area of Science:
- Pain Management
- Pharmacology
- Neurology
Background:
- Dronabinol, a synthetic delta-9-tetrahydrocannabinol, is used for refractory chronic pain.
- Prescription patterns and efficacy in France since 2004 were previously uninvestigated.
Purpose of the Study:
- To investigate the prescription practices of dronabinol for chronic pain in France.
- To assess patient profiles, reasons for prescription, and treatment outcomes.
Main Methods:
- A descriptive study utilizing questionnaires sent to French prescribers of dronabinol in 2017.
- Data collected on prescriber type, patient demographics, indications, efficacy, and side effects.
Main Results:
- 26 prescribers reported on 191 patients treated with dronabinol.
- Common indications included multiple sclerosis (49.7%) and central neuropathic pain (36.6%).
- 59% of patients experienced a 30-50% pain reduction; treatment duration varied from 1 month to 6 years.
Conclusions:
- This study provides the first insight into dronabinol prescription practices in France.
- Further research is needed to optimize its use and define its role in pain management.
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