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Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis
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Yellow nail syndrome.

Allie Preston1, Kirstin Altman2, Gregory Walker2

  • 1Texas A&M College of MedicineTempleTexas.

Proceedings (Baylor University. Medical Center)
|April 6, 2019
PubMed
Summary
This summary is machine-generated.

Yellow nail syndrome, a rare disorder, involves respiratory issues, lymphedema, and nail changes. This case highlights successful treatment with vitamin E and pulsed fluconazole for resistant nail symptoms.

Keywords:
Dystrophic nailslymphedemarespiratory complications

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Area of Science:

  • Dermatology
  • Internal Medicine
  • Pulmonology

Background:

  • Yellow nail syndrome (YNS) is a rare disorder characterized by a triad of yellow, dystrophic nails, chronic respiratory symptoms, and lymphedema.
  • Diagnosis can be challenging, particularly when respiratory symptoms are absent or pulmonary workup is negative.

Observation:

  • A patient presented with classic YNS features: yellow, thickened nails unresponsive to antifungals, lower-extremity lymphedema, and chronic cough with a negative pulmonary evaluation.
  • The nail dystrophy was refractory to standard antifungal therapy.

Findings:

  • Treatment with vitamin E demonstrated significant improvement in nail appearance and quality.
  • A regimen of pulsed fluconazole in conjunction with vitamin E further enhanced nail recovery.

Implications:

  • This case suggests that vitamin E and pulsed fluconazole are effective therapeutic options for refractory yellow nail syndrome.
  • Further research into the underlying mechanisms and optimal treatment strategies for YNS is warranted.