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Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder
Wenhao Deng1, Bin Zhang1, Wenjin Zou2
1Department of Early Intervention, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Frontiers in Psychiatry
|April 6, 2019
Summary
Early bipolar disorder (BD) shows brain network abnormalities. Degree centrality (DC) deficits in temporal regions correlate with attention and psychomotor speed, suggesting potential early diagnostic markers for BD.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Delayed diagnosis of bipolar disorder (BD) is a significant clinical challenge.
- Reliable neurobiological markers are needed to enhance diagnostic validity in early-stage BD.
- Degree centrality (DC) offers a potential method to visualize neuronal network abnormalities.
Purpose of the Study:
- To identify early neurobiological markers for bipolar disorder (BD).
- To measure resting-state degree centrality (DC) abnormalities in early BD.
- To assess cognitive deficits, including attention and psychomotor speed, in relation to DC.
Main Methods:
- Recruited 23 patients with early BD (illness duration <2 years) and 46 healthy controls.
- Measured resting-state functional magnetic resonance imaging (fMRI) data to calculate DC.
- Performed correlation analyses between DC and cognitive performance indicators.
Main Results:
- Patients with early BD exhibited DC abnormalities in frontal, temporal, and cerebellar regions.
- Significant correlations were found between psychomotor speed and DC in the superior and inferior temporal gyri.
- Attention indicators were associated with DC in the inferior temporal gyrus in early BD patients.
Conclusions:
- Degree centrality (DC) abnormalities in neural emotion regulation circuits are present in early bipolar disorder.
- Correlations between cognitive deficits (attention, psychomotor speed) and temporal DC abnormalities may serve as early diagnostic markers for BD.
- These findings highlight the potential of neuroimaging markers for improving early detection of bipolar disorder.
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