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Related Concept Videos

Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Introduction to Lymphatic and Immune System01:22

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Lymphatic Vessels and Lymph Transport01:16

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Lymphatic Function in Autoimmune Diseases.

Noa Schwartz1,2, Madhavi Latha S Chalasani1, Thomas M Li1

  • 1HSS Research Institute, Hospital for Special Surgery, New York, NY, United States.

Frontiers in Immunology
|April 6, 2019
PubMed
Summary
This summary is machine-generated.

Lymphatic vessels are crucial for immune function and clearing inflammation. Lymphatic dysfunction may play a role in autoimmune diseases like rheumatoid arthritis, with potential benefits from manual therapies.

Keywords:
autoimmune diseaselymphatic massagelymphaticsrheumatoid arthritissclerodermasystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Vascular Biology
  • Rheumatology

Background:

  • Lymphatic vessels are essential for fluid balance, immune cell transport, and immune tolerance.
  • Dysfunction of lymphatic vessels is increasingly implicated in the development and progression of autoimmune diseases.
  • Rheumatic autoimmune diseases, including rheumatoid arthritis, scleroderma, lupus, and dermatomyositis, involve complex immune system dysregulation.

Purpose of the Study:

  • To review the current understanding of lymphatic vessel roles in specific rheumatic autoimmune diseases.
  • To explore the potential contribution of lymphatic dysfunction to the pathophysiology of these conditions.
  • To consider the therapeutic potential of manual therapies for improving lymphatic function in autoimmune diseases.

Main Methods:

  • Literature review of existing research on lymphatic vessels and autoimmune diseases.
  • Analysis of the functional interplay between lymphatic systems and immune responses.
  • Exploration of evidence supporting manual therapies in modulating lymphatic function.

Main Results:

  • Lymphatic dysfunction is a potential factor in the pathogenesis of rheumatoid arthritis, scleroderma, lupus, and dermatomyositis.
  • The review highlights the critical role of lymphatic vessels in maintaining immune homeostasis and resolving inflammation.
  • Preliminary evidence suggests manual therapies may influence lymphatic drainage and immune modulation.

Conclusions:

  • Lymphatic vessel health is integral to immune system regulation and may be compromised in rheumatic autoimmune diseases.
  • Targeting lymphatic function represents a potential therapeutic avenue for managing autoimmune conditions.
  • Further research is warranted to validate the efficacy of manual therapies in improving lymphatic function and clinical outcomes in autoimmune diseases.