Long non-coding RNA: The functional regulator of mesenchymal stem cells

Area of Science:

• Stem Cell Biology
• Molecular Biology
• Genetics

Background:

• Mesenchymal stem cells (MSCs) are multipotent stromal cells with significant immunoregulatory and differentiation capabilities.
• MSCs hold promise for treating various diseases due to their therapeutic potential.
• Long noncoding RNAs (LncRNAs) are emerging regulators of cellular processes, including stem cell fate.

Purpose of the Study:

• To review the critical roles of LncRNAs in regulating mesenchymal stem cell (MSC) functions.
• To explore the involvement of LncRNAs in MSC-mediated disease pathogenesis.
• To discuss the diagnostic and therapeutic potential of LncRNAs in MSC-based clinical applications.

Main Methods:

• Literature review of studies investigating LncRNA-MSC interactions.
• Analysis of LncRNA mechanisms controlling MSC behavior (e.g., differentiation, immunomodulation).
• Synthesis of current knowledge on LncRNA involvement in diseases treated with MSCs.

Main Results:

• LncRNAs are extensively involved in regulating MSC proliferation, differentiation, and immunomodulatory functions.
• Dysregulation of specific LncRNAs impacts MSC therapeutic efficacy and disease progression.
• LncRNAs offer potential as biomarkers for MSC-based therapies and disease diagnosis.

Conclusions:

• LncRNAs play a pivotal role in governing MSC functions and their therapeutic applications.
• Targeting LncRNAs could optimize MSC-based treatments for various diseases.
• Further research into LncRNA-MSC interactions is crucial for advancing regenerative medicine and clinical practice.