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Updated: Jan 26, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
Chronic myelomonocytic leukemia as a transformation from polycythemia vera
Mirela Andrei1, Anita Pandey2, Boris Avezbakiyev2
1St Mary's Regional Medical Center, Lewiston, ME, USA.
Abstract:
The hallmark of Polycythemia vera (PV) is the presence of JAK2 mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 × 109/L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from PV have been described. We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2 clone. This clone carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16-by flow cytometry.
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