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Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis

JianPing Wu1, QianXia Wu1, MinYi Wu1

  • 1Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Biomed Research International
|April 6, 2019
PubMed

Insights

High serum cystatin C (CysC) levels indicate a poor prognosis in hepatitis B virus-related decompensated cirrhosis (HBV-DeCi) patients. CysC is a valuable independent biomarker for predicting short-term mortality in this population.

Area of Science:

  • Hepatology
  • Nephrology
  • Biomarker Research

Background:

  • Renal dysfunction is linked to poor prognosis in cirrhosis.
  • Serum cystatin C (CysC) is a sensitive marker for early kidney dysfunction.
  • Hepatitis B virus-related decompensated cirrhosis (HBV-DeCi) poses significant prognostic challenges.

Purpose of the Study:

  • To evaluate the prognostic significance of serum CysC in HBV-DeCi patients.
  • To determine if CysC can predict mortality in this cohort.
  • To compare CysC's prognostic value against established markers like MELD score.

Main Methods:

  • Retrospective analysis of 75 HBV-DeCi patients.
  • Utilized receiver operating characteristic (ROC) curve analysis.
  • Employed multivariable logistic regression modeling to assess independent predictors.

Main Results:

  • Nonsurvivors exhibited higher serum CysC levels than survivors.
  • Serum CysC levels positively correlated with Model for End-Stage Liver Disease (MELD) scores.
  • CysC and MELD score were independent prognostic factors; CysC predicted mortality even with normal creatinine.

Conclusions:

  • Elevated serum CysC levels are an independent predictor of 3-month mortality in HBV-DeCi.
  • Serum CysC serves as a valuable prognostic biomarker in HBV-DeCi.
  • CysC offers prognostic utility, particularly in patients without overt renal impairment.
Abstract

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