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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis

Yi-Pin Lv1, Ping Cheng1, Jin-Yu Zhang1

  • 1National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, China.

Science Advances
|April 6, 2019
PubMed

Insights

Matrix metalloproteinase-10 (MMP-10) promotes Helicobacter pylori colonization and gastritis by affecting immune cells and epithelial barrier function. Reducing MMP-10 could be a therapeutic strategy against H. pylori infection.

Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Helicobacter pylori infection is a major cause of gastritis and other gastric pathologies.
  • The interplay between gastric epithelium and the immune system is crucial in H. pylori-associated diseases.

Purpose of the Study:

  • To investigate the role of Matrix metalloproteinase-10 (MMP-10) in H. pylori infection and associated gastric pathology.
  • To elucidate the mechanisms by which MMP-10 influences bacterial colonization and inflammation.

Main Methods:

  • Analysis of MMP-10 levels in human gastric mucosa.
  • Studies in genetically modified mice (IL-22-/-, MMP-10-/-, and combined knockouts) to assess H. pylori colonization and inflammation.
  • Investigation of the MMP-10-CXCL16 axis and its effect on CD8+ T cell migration.
  • Assessment of protein expression (Reg3a, E-cadherin, zonula occludens-1) under MMP-10 influence.

Main Results:

  • MMP-10 is elevated in H. pylori-infected gastric mucosa and produced by epithelial cells.
  • MMP-10 deficiency or IL-22 deficiency attenuated H. pylori colonization and inflammation in mice.
  • MMP-10 promotes CD8+ T cell influx via the MMP-10-CXCL16 axis.
  • MMP-10 downregulates Reg3a, E-cadherin, and zonula occludens-1, impairing host defense.

Conclusions:

  • MMP-10 plays a significant pro-colonization and pro-inflammation role in H. pylori infection.
  • MMP-10 facilitates H. pylori persistence and exacerbates gastritis by compromising epithelial barrier function and modulating immune cell infiltration.

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