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Treatment preference and recruitment to pediatric RCTs: A systematic review
L Beasant1, A Brigden1, R M Parslow1
1Centre for Academic Child Health, Bristol Medical School, University of Bristol, UK.
Contemporary Clinical Trials Communications
|April 6, 2019
Summary
Patient and parent treatment preferences significantly impact recruitment and retention in pediatric randomized controlled trials (RCTs). Understanding these preferences is crucial for improving trial participation and outcomes.
Area of Science:
- Pediatric clinical trials
- Clinical trial recruitment and retention
- Patient-centered research
Background:
- Recruitment for pediatric randomized controlled trials (RCTs) faces challenges, including ethical considerations for assent and consent.
- Limited patient pools in pediatric RCTs exacerbate recruitment difficulties.
- Patient and parent treatment preferences are key factors influencing recruitment and retention in pediatric trials.
Purpose of the Study:
- To systematically review pediatric RCTs that report on treatment preference.
- To analyze the impact of patient and parent preferences on trial participation.
Main Methods:
- Conducted comprehensive database searches (MEDLINE, CINAHL, EMBASE, COCHRANE).
- Included qualitative or quantitative studies of pediatric populations (0-17 years) in RCTs reporting treatment preferences.
- Extracted data on consent, reasons for non-randomization due to preference, and preference details (e.g., parent vs. child).
Main Results:
- Fifty-two studies were included in the review.
- The percentage of eligible families declining RCT participation due to treatment preference ranged from 2% to 70%.
- Inconsistent reporting of participant flow and recruitment data limited extraction of withdrawal reasons related to preference.
Conclusions:
- Family treatment preferences frequently influence pediatric RCT recruitment.
- While children appear to have treatment preferences, this is seldom documented.
- Further research is necessary to elucidate the drivers of preference and its effects on RCT recruitment, retention, and outcomes.
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