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Cervical Esophageal Cancers: Challenges and Opportunities
Michael Buckstein1, Jerry Liu2
1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, 1184 5th Avenue, First Floor, New York, NY, 10029, USA. michael.buckstein@mountsinai.org.
Current Oncology Reports
|April 6, 2019
Summary
Optimal management for cervical esophageal cancers (CECs) involves definitive chemoradiation, with surgery reserved for salvage. Recent strategies like IMRT and induction chemotherapy show promise for improving outcomes in this rare cancer subset.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Cervical esophageal cancers (CECs) represent a rare and distinct subtype of esophageal malignancies.
- Current management and outcomes for CECs remain suboptimal, necessitating a review of therapeutic strategies.
Purpose of the Study:
- To explore current data on the optimal management of cervical esophageal cancers.
- To identify strategies that improve oncological outcomes and minimize morbidity in CEC patients.
Main Methods:
- Review of recent data on therapeutic interventions for CEC.
- Analysis of strategies including selective surgery, chemoradiation (CRT) versus radiation (RT) alone, dose escalation, intensity-modulated radiation therapy (IMRT), and induction chemotherapy.
Main Results:
- Definitive chemoradiation appears to be the optimal approach, with surgery reserved for selective salvage cases.
- Intensity-modulated radiation therapy (IMRT) may offer benefits independent of dose escalation.
- Induction chemotherapy shows potential for "chemoselection," though its overall benefit is still under investigation.
Conclusions:
- The optimal management strategy for CEC involves definitive chemoradiation, reserving surgery for salvage.
- Further research is needed to clarify the benefits of dose escalation and induction chemotherapy in CEC treatment.
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