Related Experiment Video
Updated: Jan 26, 2026
10:15
Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
Published on: November 1, 2019
13.3K
Effects of Curcumin on Microglial Cells
Faezeh Ghasemi1, Hossein Bagheri2, George E Barreto3,4
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Neurotoxicity Research
|April 6, 2019
Summary
Curcumin, a compound from turmeric, can inhibit microglia activation, reducing inflammation and protecting against neurodegenerative diseases like Alzheimer's and Parkinson's. This review explores curcumin's mechanisms in modulating microglia for neurological health.
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Background:
- Microglia are CNS immune cells regulating homeostasis but can cause neuroinflammation when activated.
- Excessive neuroinflammation contributes to neurodegenerative diseases (NDs) like Alzheimer's (AD) and Parkinson's (PD).
- Curcumin, a phytochemical from Curcuma longa, possesses anti-inflammatory and neuroprotective properties.
Purpose of the Study:
- To review the effects of curcumin on microglia.
- To explore the underlying mechanisms of curcumin's action on microglia.
- To highlight curcumin's potential in mitigating neuroinflammation and NDs.
Main Methods:
- Literature review of studies on curcumin and microglia.
- Analysis of curcumin's molecular targets and pathways.
- Synthesis of evidence on curcumin's anti-inflammatory effects in the CNS.
Main Results:
- Curcumin inhibits microglia activation and the release of pro-inflammatory mediators (cytokines, NO, COX-2).
- Curcumin exhibits antioxidant, anti-amyloidogenic, and anti-mutagenic properties relevant to NDs.
- Curcumin demonstrates pleiotropic effects, modulating multiple pathways involved in neuroinflammation.
Conclusions:
- Curcumin effectively modulates microglia activity, offering a therapeutic strategy for neuroinflammation.
- Its anti-inflammatory and neuroprotective actions make it a promising agent for preventing or treating NDs.
- Further research into curcumin's mechanisms can optimize its use in neurological disorders.
More Related Videos
07:23Magnetic Isolation of Microglial Cells from Neonate Mouse for Primary Cell Cultures
Published on: July 25, 2022
3.7K
12:48In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
Published on: May 11, 2015
11.1K
Related Concept Videos
02:19Buffer Effectiveness
55.0K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.0K
03:26Framing Effects
7.9K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.9K
02:59Biological Effects of Radiation
17.7K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.7K
01:21Self-Awareness and Its Effects
304
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
304
01:24Effects of feedback
1.0K
Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
1.0K
01:25Effects of Creep
428
Creep in concrete, the gradual deformation under prolonged stress, significantly impacts the integrity of structures. For reinforced concrete beams, it can be a vital design consideration, as it increases deflection, sometimes necessitating additional design measures. In columns, especially slender ones under eccentric loads, creep can cause buckling, compromising their stability. However, creep can be beneficial in indeterminate structures by mitigating stresses that arise from shrinkage,...
428