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Updated: Jan 26, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Enantioselective Total Synthesis of Pseudopteroxazole and Ileabethoxazole
Xuan Zhang1, Xianhe Fang1, Miao Xu1
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Abstract:
Enantioselective total syntheses of pseudopteroxazole (1) and ileabethoxazole (2) are presented. The two original stereocenters were constructed in excellent enantioselectivity and good diastereoselectivity through Carreira's asymmetric dual catalytic allylation, which shows potential for accessing diastereoisomers at C2 and C3 of 1 and 2. Cationic cyclizations of 13 and 24 demonstrated an effective pathway for the construction of the opposite configurations at C1 in 1 and 2. Additionally, an approach for the introduction of methyl at C4 is a feasible solution for structural modifications at C4 in 1 and 2.
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