Immunological comparison of heat-shock proteins and alpha-crystallin

It has been shown using ELISA and affinity chromatography, that extracts from heat-shocked Drosophila melanogaster larvae and cultured cells react with monoclonal antibodies raised against bovine alpha-crystallin. It is suggested that this cross-reactivity is associated with the region of the sequence corresponding to residues 98-108 of the bovine alpha A-crystallin chain. This region may be important for the functions of both alpha-crystallin and the heat-shock proteins.