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Updated: Jan 26, 2026
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Daratumumab in multiple myeloma
Ajay K Nooka1, Jonathan L Kaufman1, Craig C Hofmeister1
1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Abstract:
The development of effective monoclonal antibodies for the treatment of myeloma has been a long journey of clinical and drug development. Identification of the right target antigen was a critical part of the process. CD38 as a target has been considered for some time, but clinically, daratumumab, a CD38 monoclonal antibody, was the first to be tested, and it has delivered the best clinical responses as a single agent to date. Its proven safety and efficacy in combination with other antimyeloma agents have led to several US Food and Drug Administration approvals for treating myeloma. Furthermore, the results of early trials in the induction therapy setting have demonstrated a beneficial role when it is added to the existing induction regimens. This review summarizes the importance of CD38 as a target and examines the clinical development of the CD38 monoclonal antibody daratumumab and its clinical significance in combination regimens in both patients with relapsed/refractory myeloma and patients with newly diagnosed myeloma.
Insights
Daratumumab, a CD38 monoclonal antibody, is a key advancement in myeloma treatment, showing significant clinical responses as a single agent and in combination therapies for both newly diagnosed and relapsed patients.
Area of Science:
- Oncology
- Immunotherapy
- Drug Development
Background:
- Monoclonal antibodies targeting myeloma have undergone extensive development.
- Identifying effective target antigens is crucial for therapeutic success.
Purpose of the Study:
- To review the significance of CD38 as a target antigen in multiple myeloma.
- To examine the clinical development and significance of daratumumab, a CD38 monoclonal antibody.
Main Methods:
- Review of clinical trials and drug development data for CD38-targeted therapies.
- Analysis of daratumumab's efficacy as a single agent and in combination regimens.
Main Results:
- Daratumumab is the first clinically tested CD38 monoclonal antibody, demonstrating superior responses.
- Proven safety and efficacy in combination with other agents, leading to FDA approvals.
- Early trials indicate a beneficial role in induction therapy for myeloma.
Conclusions:
- CD38 is a validated and important target for multiple myeloma treatment.
- Daratumumab has established clinical significance in both relapsed/refractory and newly diagnosed myeloma settings.
- Combination regimens including daratumumab offer improved therapeutic outcomes.
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