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Ageing and sources of transcriptional heterogeneity

Chrysa Nikopoulou1, Swati Parekh1, Peter Tessarz1,2

  • 1Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, Germany.

Biological Chemistry
|April 6, 2019
PubMed

Keywords:
cellular heterogeneitychromatin dynamicsepigeneticssingle-cell biologystochastic gene expressiontranscriptional noise

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Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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