Related Experiment Video
Updated: Jan 26, 2026

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
Published on: September 20, 2011
Signaling by adenosine receptors-Homeostatic or allostatic control?
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Abstract:
Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed "normal" physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.
More Related Videos
Related Concept Videos
Homeostatic Imbalance
However, sometimes these feedback loops fail,...
Signal Sequences and Sorting Receptors
Insulin: The Receptor and Signaling Pathways
Homeostatic Imbalances in Body Temperature
Yeast Signaling
Internal Receptors

