Related Experiment Video
Updated: Aug 9, 2026
06:39
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Buccal nitroglycerin in congestive cardiac failure: a multicentre study
The Journal of International Medical Research
|January 1, 1986
Summary
Buccal nitroglycerin improved congestive cardiac failure symptoms in elderly patients. This additional therapy demonstrated sustained benefits in symptom reduction and functional capacity over a 6-month study period.
Area of Science:
- Cardiology
- Geriatrics
- Pharmacology
Background:
- Elderly patients often present with congestive cardiac failure (CCF).
- Standard CCF therapies (diuretics, inotropic agents) may not fully resolve symptoms.
- Exploring adjunctive treatments is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of buccal nitroglycerin as an add-on therapy for elderly patients with CCF.
- To assess symptom improvement and functional classification changes.
- To determine the duration of therapeutic benefit.
Main Methods:
- A study involving 192 elderly patients diagnosed with CCF.
- Patients received standard CCF therapy plus buccal nitroglycerin.
- Assessment of symptoms and functional classification over a 6-month period.
Main Results:
- Symptom improvements were observed within 14 days of initiating buccal nitroglycerin.
- Enhanced functional classification was noted in the patient cohort.
- These positive effects were maintained throughout the entire 6-month study duration.
Conclusions:
- Buccal nitroglycerin is an effective adjunctive therapy for elderly patients with CCF.
- The addition of buccal nitroglycerin leads to rapid and sustained symptom relief.
- This treatment offers a valuable option for managing refractory CCF symptoms in the elderly.
Related Concept Videos
01:22Heart Failure Drugs: β-Blockers
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
01:16Antianginal Drugs: Nitrates and β-Blockers
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
01:18Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...
01:29Angina III: Clinical Manifestations and Assessment
Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
01:26Angina IV: Management
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
01:20Angina V: Nursing Management
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...