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Related Experiment Video

Updated: Jan 26, 2026

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MRAP2 regulates endometrial receptivity and function.

Marco D'Aurora1, Federica Romani2, Sara Franchi1

  • 1Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy; Functional Genetics Unit, Center of Excellence on Aging (Ce.S.I.-MeT), Via Luigi Polacchi 11, 66100 Chieti, Italy.

Gene
|April 6, 2019
PubMed
Summary

MRAP2 gene expression is significantly higher in women with unexplained infertility, suggesting it plays a key role in endometrial receptivity and embryo implantation success.

Keywords:
Endometrial receptivityGene expressionInfertilityMRAP2

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Area of Science:

  • Reproductive Biology
  • Genetics
  • Gynecology

Background:

  • Successful embryo implantation requires synchronized blastocyst competence and endometrial receptivity.
  • Potential modulators of endometrial receptivity, including OVGP1, MRAP2, ZCCHC12, and HAP1, have been identified.

Purpose of the Study:

  • To evaluate the gene expression of OVGP1, MRAP2, ZCCHC12, and HAP1 in the endometrium of infertile women.
  • To investigate the role of MRAP2 in endometrial receptivity and its potential link to infertility.

Main Methods:

  • Gene expression analysis using quantitative reverse transcription polymerase chain reaction (qRT-PCR).
  • Protein expression analysis via western blot.
  • Immunohistochemistry for MRAP2 localization.
  • Light microscopy for endometrial morphology assessment.

Main Results:

  • MRAP2 gene expression was significantly upregulated in women with unexplained infertility compared to controls.
  • Western blot confirmed the increased expression of MRAP2.
  • MRAP2 was primarily localized in the epithelial cells of uterine glands.
  • Uterine gland epithelium showed hypertrophy in women with unexplained infertility.

Conclusions:

  • MRAP2 may act as a mediator of endometrial receptivity, potentially influencing endometrial stability.
  • The findings suggest MRAP2's involvement in the pathophysiology of unexplained infertility.