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Amorphous pullulan trehalose microparticle platform for respiratory delivery.

Nicholas B Carrigy1, Mani Ordoubadi1, Yushan Liu1

  • 1Department of Mechanical Engineering, University of Alberta, Edmonton, Canada.

International Journal of Pharmaceutics
|April 6, 2019
PubMed
Summary
This summary is machine-generated.

Spray drying pullulan trehalose powder enhances thermal stability for inhalation delivery. This stable powder shows promising aerosol performance and compatibility with pressurized metered-dose inhalers for improved drug distribution.

Keywords:
BiologicsDroplet chainParticle engineeringRadial glass transition temperatureRaman spectroscopySpray drying

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biotechnology

Background:

  • Spray drying offers enhanced thermal stability for biologics and small molecules compared to liquid forms.
  • This technique facilitates distribution in regions lacking cold chain infrastructure.

Purpose of the Study:

  • To characterize spray-dried pullulan trehalose powder for inhalation applications.
  • To evaluate its manufacturability, physical stability, device compatibility, and aerosol performance.

Main Methods:

  • Spray drying of pullulan trehalose powder.
  • Characterization of powder properties (manufacturability, flowability, cohesiveness, compressibility).
  • Assessment of physical stability under various storage conditions and propellants.
  • Evaluation of aerosol performance using a dry powder inhaler and pressurized metered-dose inhaler compatibility.

Main Results:

  • Demonstrated good spray drying yield and powder flowability.
  • Exhibited short-term physical stability at ambient and elevated temperatures, including in HFA propellants.
  • Theoretical modeling predicted a high glass transition temperature at the microparticle surface.
  • Achieved high dispersibility, optimal particle size for inhalation, and adequate total lung dose from a dry powder inhaler.
  • Showed compatibility with pressurized metered-dose inhalers without morphological changes.

Conclusions:

  • The pullulan trehalose platform is suitable for respiratory drug delivery.
  • Spray-dried powder demonstrates potential for stable, effective inhalation therapies.
  • This formulation offers a promising alternative for drug delivery, especially in resource-limited settings.