Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Epigenetic Regulation01:37

Epigenetic Regulation

3.8K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.8K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.1K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.1K
Whole Body Regeneration01:33

Whole Body Regeneration

4.1K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.1K
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinoic acid regulates foveal development in the human retina.

Cell reports·2026
Same author

A cell fate specification and transition mechanism for human foveolar cone subtype patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Decoding cell-class specific roles of non-coding variants in human retina.

Scientific reports·2025
Same author

The genesis of neurons and glia in the developing retina.

Current topics in developmental biology·2025
Same author

CUT&TIME captures the history of open chromatin in developing neurons.

bioRxiv : the preprint server for biology·2025
Same author

Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 26, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Epigenetics in neuronal regeneration.

Leah S VandenBosch1, Thomas A Reh1

  • 1Department of Biological Structure, Molecular and Cellular Biology Graduate Program, Institute for Stem Cells and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, 98195, United States.

Seminars in Cell & Developmental Biology
|April 6, 2019
PubMed
Summary
This summary is machine-generated.

Mammals cannot regenerate neuronal tissue, but studying epigenetic factors like DNA accessibility, histone acetylation, and DNA methylation in regenerative species offers therapeutic potential for neural repair.

Keywords:
CochleaHistoneNeurogenesisRetinaSpinal cord

More Related Videos

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

4.2K
Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.2K

Related Experiment Videos

Last Updated: Jan 26, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K
Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

4.2K
Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.2K

Area of Science:

  • Neuroscience
  • Epigenetics
  • Regenerative Medicine

Background:

  • Mammalian neuronal tissue damage results in permanent function loss.
  • Unlike mammals, amphibians and teleost fish exhibit significant neuronal tissue regeneration.
  • Understanding native regeneration mechanisms can guide therapeutic development for non-regenerative systems.

Purpose of the Study:

  • To review and compare evidence of epigenetic roles in neuronal tissue development and regeneration.
  • To focus on the neural retina, inner ear, and spinal cord across regenerative and non-regenerative species.

Main Methods:

  • Comparative analysis of epigenetic mechanisms in development and regeneration.
  • Review of studies investigating DNA accessibility, histone acetylation, and DNA methylation in neural regeneration.
  • Examination of findings from both broadly acting and targeted epigenetic manipulations.

Main Results:

  • Epigenetic factors, including DNA accessibility, histone acetylation, and DNA methylation, play a role in regulating gene expression for regeneration.
  • Evidence suggests these epigenetic changes are crucial for initiating and sustaining the regenerative process in key neural systems.
  • Broad experimental manipulations have established a foundational role for epigenetics, though specific contributions require further investigation.

Conclusions:

  • Epigenetic modifications are key regulators of neuronal regeneration across different species.
  • Targeted epigenetic approaches are essential for dissecting specific regulatory roles and developing novel regenerative therapies for mammals.
  • Further research into epigenetics holds promise for stimulating neural repair in humans.