Related Experiment Video

Updated: Jan 26, 2026

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.2K

Is the era of bilateral internal thoracic artery grafting coming for diabetic patients? An updated meta-analysis

Pengyu Zhou1, Peng Zhu1, Zhiqiang Nie2

  • 1Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

The Journal of Thoracic and Cardiovascular Surgery
|April 7, 2019
PubMed

Insights

Bilateral internal thoracic artery grafting offers improved long-term survival for diabetic patients, despite initial concerns about sternal wound complications. Using a skeletonized technique mitigates infection risk, making it a viable option for enhanced patient outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Diabetic Patient Care

Background:

  • Bilateral internal thoracic artery (BITA) grafting in diabetic patients is debated due to sternal wound infection risks.
  • Comparing BITA with single internal thoracic artery (SITA) grafting is crucial for optimizing outcomes in this population.

Purpose of the Study:

  • To conduct a meta-analysis comparing the safety and efficacy of SITA versus BITA grafting in diabetic patients.
  • To evaluate sternal wound complications, in-hospital mortality, and long-term survival rates.

Main Methods:

  • A comprehensive search of four electronic databases (PubMed, Cochrane Library, Embase, ISI Web of Knowledge) was performed.
  • Included prospective randomized trials and observational studies comparing SITA and BITA grafting in diabetic patients.

Main Results:

  • Analysis of 17 studies (129,871 diabetic patients) showed higher deep sternal wound infection rates with BITA (3.26%) versus SITA (1.70%).
  • Skeletonized harvesting eliminated the increased infection risk for BITA.
  • BITA grafting was associated with lower long-term overall mortality (HR 1.41) and cardiac mortality (HR 3.15) compared to SITA.

Conclusions:

  • BITA grafting enhances long-term survival in diabetic patients, particularly when using the skeletonized technique.
  • Skeletonized BITA grafting is recommended for routine use in diabetic patients to improve long-term outcomes without increasing infection risk.
Abstract

Keywords:
bilateral internal thoracic artery graftingcoronary artery bypass graftingdiabetesskeletonization

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K
A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position11:20

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Published on: April 1, 2022

3.5K

Related Concept Videos

Thoracic Aorta01:15

Thoracic Aorta

The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.6K
Internal Energy02:00

Internal Energy

The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.6K
Internal Energy01:29

Internal Energy

The internal energy of a thermodynamic system is the sum of the kinetic and potential energies of all the molecules or entities in the system. The kinetic energy of an individual molecule includes contributions due to its rotation and vibration, as well as its translational energy. The potential energy is associated only with the interactions between one molecule and the other molecules of the system. Neither the system's location nor its motion is of any consequence as far as the internal...
6.9K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.4K
The Thoracic Cage: Sternum01:17

The Thoracic Cage: Sternum

The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
5.9K
The Thoracic Cage: Ribs01:20

The Thoracic Cage: Ribs

Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
8.4K