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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
Intraventricular hemorrhage and posthemorrhagic hydrocephalus in preterm infants: diagnosis, classification, and
Paola Valdez Sandoval1, Paola Hernández Rosales1, Deyanira Gabriela Quiñones Hernández1
1Department of Clinical Sciences, Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Avenida General Ramón Corona 2514, Guadalajara, 45138, Mexico.
Insights
Intraventricular hemorrhage in preterm infants can cause developmental delays. Current diagnosis uses cranial ultrasound, but standardized treatment protocols are lacking, highlighting the need for more research.
Area of Science:
- Neonatal Neurology
- Pediatric Neurosurgery
Background:
- Intraventricular hemorrhage (IVH) is a critical neurological complication in preterm and very low birth weight infants.
- IVH can result in significant long-term motor, language, and cognitive developmental impairments.
Purpose of the Study:
- To provide a comprehensive overview of the current knowledge regarding the diagnosis, classification, and treatment of intraventricular hemorrhage in neonates.
Main Methods:
- A systematic review of existing literature was conducted.
Main Results:
- Cranial ultrasound is the primary diagnostic tool for identifying and grading IVH using the modified Papile scale.
- Intervention protocols remain controversial, with ongoing debate regarding optimal neurosurgical procedures and shunt conversion parameters.
- White matter damage is identified as the most significant prognostic factor for neurodevelopmental outcomes.
Conclusions:
- Further research and evidence are necessary to establish standardized treatment protocols for intraventricular hemorrhage.
- Standardization aims to optimize neurodevelopmental outcomes for affected preterm infants.
Purpose:
Intraventricular hemorrhage is the most important adverse neurologic event for preterm and very low weight birth infants in the neonatal period. This pathology can lead to various delays in motor, language, and cognition development. The aim of this article is to give an overview of the knowledge in diagnosis, classification, and treatment options of this pathology.
Method:
A systematic review has been made.
Results:
The cranial ultrasound can be used to identify the hemorrhage and grade it according to the modified Papile grading system. There is no standardized protocol of intervention as there are controversial results on which of the temporizing neurosurgical procedures is best and about the appropriate parameters to consider a conversion to ventriculoperitoneal shunt. However, it has been established that the most important prognosis factor is the involvement and damage of the white matter.
Conclusion:
More evidence is required to create a standardized protocol that can ensure the best possible outcome for these patients.
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