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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Related Experiment Video

Updated: Jan 26, 2026

Studying Orthodontic Tooth Movement in Mice
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Serotonin and orthodontic tooth movement.

Thomas Dhenain1, Francine Côté1, Tereza Coman2

  • 1Institut Imagine, INSERM U1163, CNRS ERL, 8254, Hôpital Necker, Laboratoire d'excellence GR-Ex, Paris, France.

Biochimie
|April 7, 2019
PubMed
Summary
This summary is machine-generated.

Peripheral serotonin influences bone remodeling during orthodontic tooth movement. Understanding this local serotonergic system can lead to improved orthodontic treatment strategies and reduced adverse effects.

Keywords:
FluoxetineOrthodontic tooth movementOrthodontically induced root resorptionSelective serotonine reuptake inhibitorsSerotonin

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Area of Science:

  • Biomedical Science
  • Orthodontics
  • Cellular Biology

Background:

  • Peripheral serotonin plays a role in various organ functions, including bone tissue.
  • A local serotonergic system in bone influences cellular and molecular mechanisms of bone turnover.
  • Orthodontic treatment involves bone remodeling, an inflammatory process triggered by applied forces.

Purpose of the Study:

  • To review the role of peripheral serotonin in regulating bone remodeling during orthodontic tooth movement.
  • To discuss the impact of serotonin on alveolar bone inflammation in the context of orthodontics.
  • To explore potential new orthodontic strategies based on serotonin's effects.

Main Methods:

  • Literature review focusing on peripheral serotonin and bone remodeling.
  • Analysis of cellular and molecular mechanisms involved in orthodontic tooth movement.
  • Discussion of inflammatory processes and their regulation by serotonin.

Main Results:

  • Evidence suggests a local serotonergic system significantly impacts bone turnover.
  • Serotonin's differential effects on alveolar bone inflammation are crucial for orthodontic efficacy.
  • Factors influencing serotonin levels may affect orthodontic treatment outcomes.

Conclusions:

  • Peripheral serotonin is a key regulator of bone remodeling during orthodontic treatment.
  • Targeting the serotonergic system could offer novel therapeutic approaches in orthodontics.
  • Further research into serotonin's role may optimize orthodontic treatment efficacy and minimize side effects.