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Cell Population Analyses During Skin Carcinogenesis
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Cell Population Analyses During Skin Carcinogenesis

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HPV and skin carcinogenesis.

Massimo Tommasino1

  • 1Infections and Cancer Biology Group, International Agency for Research on Cancer (IARC), Lyon, France.

Papillomavirus Research (Amsterdam, Netherlands)
|April 7, 2019
PubMed
Summary
This summary is machine-generated.

Cutaneous beta human papillomaviruses (HPVs) and UV radiation are involved in skin cancer. Beta HPVs facilitate UV-induced DNA mutations, promoting cancer development via a hit-and-run mechanism.

Keywords:
Cutaneous beta HPVsCutaneous squamous cell carcinomaUltraviolet radiation

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Area of Science:

  • Dermatology
  • Oncology
  • Virology

Background:

  • Cutaneous beta human papillomaviruses (HPVs) and ultraviolet (UV) radiation are implicated in cutaneous squamous cell carcinoma development.
  • Beta HPVs are thought to act via a hit-and-run mechanism, crucial in early carcinogenesis but not for maintaining malignancy.

Purpose of the Study:

  • To elucidate the role of beta HPVs and UV radiation in skin carcinogenesis.
  • To understand the mechanism by which beta HPVs contribute to UV-induced skin cancer.

Main Methods:

  • Review of epidemiological and biological studies.
  • Analysis of experimental models investigating beta HPV oncoproteins (E6 and E7).

Main Results:

  • Beta HPVs, particularly E6 and E7 oncoproteins, promote keratinocyte proliferation and circumvent UV-induced cellular stress.
  • This allows infected cells to survive with accumulated DNA mutations, increasing susceptibility to malignancy.
  • UV radiation acts as the primary driver, while beta HPVs facilitate the accumulation of these mutations.

Conclusions:

  • Beta HPVs act as facilitators in skin carcinogenesis by enabling keratinocytes to accumulate UV-induced DNA damage.
  • This interaction between beta HPVs and UV radiation is a key pathway in the development of cutaneous squamous cell carcinoma.