Targeting drug delivery within the suprachoroidal space

Area of Science:

• Ophthalmology
• Drug Delivery Systems
• Biomedical Engineering

Background:

• The suprachoroidal space (SCS) is an anatomical space in the eye between the sclera and choroid.
• SCS drug delivery is a promising new route for targeting ocular tissues.
• Clinical trials have demonstrated the safety and efficacy of SCS drug delivery.

Purpose of the Study:

• To review novel technologies for drug delivery within the suprachoroidal space (SCS).
• To discuss methods for precise targeting within the SCS at various ocular sites.
• To highlight advancements in SCS drug delivery for posterior, anterior, or entire eye targeting.

Main Methods:

• Review of recent studies and novel technologies for SCS drug delivery.
• Discussion of techniques including iontophoresis, hydrogels, particle emulsions, viscous fluids, and microstents.
• Categorization of technologies based on targeting specific SCS regions (posterior, anterior, entire).

Main Results:

• Multiple methods have been developed for precise drug targeting within the SCS.
• Technologies enable targeting of specific ocular regions like the macula and ciliary body.
• Advancements allow for drug delivery throughout the entire SCS or to localized areas.

Conclusions:

• Novel technologies are enhancing the precision and effectiveness of SCS drug delivery.
• These advancements offer improved therapeutic options for chorioretinal diseases.
• Further research into these technologies will optimize ocular drug delivery strategies.