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Incidence and survival of peritoneal malignant mesothelioma between 1989 and 2015: A population-based study

N Le Stang1, V Bouvier2, O Glehen3

  • 1Multicenter National Mesothelioma Registry (MESONAT), Léon Bérard Cancer Center, Lyon, F-69008, France; FRANCIM Network, Toulouse, F-31000, France.

Cancer Epidemiology
|April 7, 2019
PubMed
Abstract

Insights

Peritoneal malignant mesothelioma incidence slightly increased in France from 1989-2015. Survival improved for diagnoses after 2000, epithelioid type, and women, who have a better prognosis.

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Examines the incidence and survival trends of peritoneal malignant mesothelioma in France.
  • Utilizes data from the French network of cancer registries spanning 1989-2015.
  • Addresses the rarity of population-based studies for this disease.

Observation:

  • Incidence in men rose from 0.07 to 0.10 per 100,000 person-years.
  • Incidence in women showed a lower increase, ranging from 0.04 to 0.11.
  • Median survival remains approximately 1 year.

Findings:

  • A diagnosis after 2000 significantly improved prognosis (HR=1.76, p=0.013).
  • Epithelioid histological type was associated with better survival (p=0.003).
  • Women had a 5-year mortality risk half that of men (HR=0.55, p=0.001).

Implications:

  • Highlights improved survival factors for peritoneal mesothelioma.
  • Suggests potential for targeted interventions based on histology and sex.
  • Underscores the need for continued surveillance of this rare cancer.
Keywords:
IncidenceMalignant peritoneal mesotheliomaSurvivalTime trends

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